Milkweed contains cardiac glycosides and the plant is toxic to livestock, which raises a reasonable question about the honey.
The cardiac glycosides (cardenolides) are best known from the latex and leaves, but they are in the nectar too: bumble bees fed milkweed nectar lost heat tolerance in a 2025 study, matching the effect of a purified cardenolide. How much reaches honey, after bees process and blend the nectar, has had little study, and HoneyHQ found no reported poisoning from milkweed honey in the sources read.
What this does not claim: This is not a claim that milkweed honey is unsafe. It is a statement that the plant's toxicity is real, that it reaches the nectar, and that whether it reaches the honey in meaningful amounts has not been measured in the sources read.
- Secondary compounds in milkweed nectar negatively impact thermal tolerance in bumble bees — Ecology and Evolution (2025) · Peer-reviewed article Link