Manuka honey contains methylglyoxal, which gives it antibacterial activity in laboratory tests that other honeys do not have.
Well established as chemistry. Dihydroxyacetone in Leptospermum nectar converts to methylglyoxal as the honey matures, and methylglyoxal inhibits bacterial growth in vitro. This non-peroxide activity is what distinguishes manuka from honeys whose antibacterial effect comes from hydrogen peroxide and disappears in the presence of catalase.
What this does not claim: In vitro activity is not a clinical effect. Inhibiting bacteria in a dish says nothing about what happens to bacteria in a person who eats a spoonful, where the honey is diluted, swallowed and digested. A higher MGO number means more of a compound, not more benefit.
- Identification of methylglyoxal as the dominant antibacterial constituent of manuka honey — Molecular Nutrition and Food Research / Carbohydrate Research (2008) · Peer-reviewed article
- UMF grading and the New Zealand manuka honey definition — UMF Honey Association / New Zealand Ministry for Primary Industries · Industry body